Mycalamide D, a new cytotoxic amide from the New Zealand marine sponge Mycale species

Authors
West, LM Northcote, PT Hood, KA Miller, JH Page, MJ
Citation
Lm. West et al., Mycalamide D, a new cytotoxic amide from the New Zealand marine sponge Mycale species, J NAT PROD, 63(5), 2000, pp. 707-709
Citations number
7
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
63
Issue
5
Year of publication
2000
Pages
707 - 709
Database
ISI
SICI code
0163-3864(200005)63:5<707:MDANCA>2.0.ZU;2-S
Abstract
A new mycalamide, mycalamide D (3), has been isolated from the New Zealand marine sponge Mycale sp. This new metabolite, in which the C13-O-methyl gro up of mycalamide A (1) is replaced by a hydrogen atom, was found to be cyto toxic to a range of mammalian cell lines, with a potency approximately 20-f old less than that of 1.