A 33-year-old woman had intravenous drug-associated tricuspid valve infecti
ve endocarditis. Despite resolution of septic pulmonary emboli, hypoxemia p
ersisted. We report a case of right-to-left shunting across a previously in
significant patent foramen ovale documented by contrast transesophageal ech
ocardiography. Although a rare complication of tricuspid endocarditis, clin
icians should be aware of this potential correctable complication.