Efficacy and safety of oseltamivir in treatment of acute influenza: a randomised controlled trial

Background Use of some antiviral drugs for influenza infection is limited b y potential rapid emergence of resistance, We studied the efficacy and safe ty of oseltamivir, the oral prodrug of the neuraminidase inhibitor GS4071, in adults with naturally acquired laboratory-confirmed influenza. Methods We did a randomised controlled trial of 726 previously healthy non- immunised adults with febrile influenza-like illness of vp to 36 h duration . Patients were assigned oral oseltamivir 75 mg (n=243), oseltamivir 150 mg (n=245), or placebo (n=238) twice daily for 5 days. We assessed recovery b y questionnaire and temperature recordings. The primary endpoint was time t o resolution of illness in influenza-infected patients. Findings 475 (66%) patients had confirmed infection. Duration of illness wa s significantly shorter by 29 h (25% reduction, median duration 87.4 h [95% CI 73.3-104.7], p=0.02) with oseltamivir 75 mg and by 35 h (30%, 81.8 h [6 8.2-100.0], p=0.01) with oseltamivir 150 mg than with placebo (116.5 h [101 .5-137.8]). The effect of oseltamivir was apparent within 24 h of the start of treatment. In patients treated within 24 h of symptom onset, symptoms w ere alleviated 43 h (37% reduction) and 47 h (40%) earlier with oseltamivir 75 mg and 150 mg, respectively, compared with placebo (75 mg 74.5 h [68.2- 98.0], p=0.02; 150 mg 70.7 h [54.0-89.4], p=0.01; placebo 117.5 h [103.0-14 3.8]). Oseltamivir was associated with higher symptom scores, less viral sh edding, and improved health, activity, and sleep quality, and was well tole rated. Interpretation Oseltamivir was effective and well tolerated in the treatmen t of natural influenza infection in adults. The efficacy, tolerability, and ease of administration warrant further investigation in children, elderly patients, and at-risk patients.