Effect of photodynamic therapy on the mechanical strength of healed rodentskin incisions

Authors
Brouwer, PA Van der Meulen, FW Timmenga, EJF van Gemert, MJC
Citation
Pa. Brouwer et al., Effect of photodynamic therapy on the mechanical strength of healed rodentskin incisions, LASER MED S, 15(1), 2000, pp. 31-34
Citations number
24
Categorie Soggetti
Surgery
Journal title
LASERS IN MEDICAL SCIENCE
ISSN journal
02688921 → ACNP
Volume
15
Issue
1
Year of publication
2000
Pages
31 - 34
Database
ISI
SICI code
0268-8921(2000)15:1<31:EOPTOT>2.0.ZU;2-L
Abstract
A factor that might complicate the use of intraoperative photodynamic thera py (PDT) is a possible adverse effect on normal tissue recovery. In this st udy, rats with experimental skin incisions received intraoperative PDT (10 mg/kg haematoporphyrin derivative, 180 J/cm(2) laser light), immediately fo llowed by closure. Healing was evaluated by tensile strength assessment of the incisions 21 days after PDT. No significant differences between the PDT -treated group and control groups were found. We therefore concluded that w ith respect to healing of skin incisions in rats, intraoperative PDT is not contraindicated.