F. Simko et al., Effect of angiotensin-converting enzyme inhibitors on non-diseased myocardium of experimental animals: potential clinical implications, MED HYPOTH, 54(4), 2000, pp. 626-627
Citations number
12
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Angiotensin-converting enzyme (ACE) inhibitors protect the hearts of patien
ts with different levels of cardiac disorder. The greatest benefit seems to
be achieved in subjects with most severe heart failure. Moreover, ACE inhi
bition is protective also in patients without manifested heart failure but
with severe systolic left ventricular dysfunction. Data are presented that
ACE inhibitors can alter the composition of the myocardium also in control:
healthy animals. In rats and rabbits with non-diseased heart, chronic ACE
inhibition reduced fibrotic tissue concentration in the left ventricle. We
speculate that if this were applied to humans, ACE inhibition may prove to
be of potential benefit in subjects with normal systolic function but with
a trend to left ventricular filling abnormalities caused by increased ventr
icular stiffness. In these patients reduction of myocardial fibrotic tissue
might prevent deterioration of diastolic function. (C) 2000 Harcourt Publi
shers Ltd.