Effectiveness of omeprazol, clarithromycin and amoxycillin therapy to eradicate Helicobacter pylori in patients with active peptic ulcer. Preliminaryresults of GEHPY study

BACKGROUND: TO compare the effectiveness of two length of the same therapy to eradicate Helicobacter pylori in patients with non complicated active pe ptic ulcer. PATIENTS AND METHODS: 223 patients visited at primary health centres. A ran domised controlled trial was carried out to compare the results of 6 or 7 d ays of treatment with chlaritromicyn 500 mg, amoxicillin 1 g and omeprazole 20 mg, b.i.d. All patients received omeprazole for other 14 days. RESULTS: 108 patients were randomised to the 6 days group and 115 to the 7 days one. Both groups were comparable with respect to basic characteristics except for sex: the proportion of men was higher in the 6 days group (p = 0.04). 91.4% of the patients received all the treatment correctly. By inten tion to treat analysis, eradication rates were 76.9% in the 6 days group an d 77.4% in the seven days group (IC 95% of the difference from -10.5 to 11. 6). There were not statistically significant differences in eradication rat es in relation to age, sex, ulcer location, recurrence or tobacco consumpti on. CONCLUSIONS: Although eradication rates are lower than expected, in this st udy there are no differences between 6 or 7 days of therapy.