H. Fielding et al., The compatibility and stability of octreotide acetate in the presence of diamorphine hydrochloride in polypropylene syringes, PALLIAT MED, 14(3), 2000, pp. 205-208
Varying concentrations of octreotide acetate (Sandostatin(R)) and diamorphi
ne hydrochloride were prepared and stored in polypropylene syringes at 37 d
egrees C in the dark. The solutions were analysed for octreotide acetate co
ntent using a validated HPLC method at regular intervals over a 48-h period
. The results indicate that octreotide acetate remains stable in the presen
ce of diamorphine hydrochloride at 37 degrees C for 24 h. in addition, the
solutions prepared maintained their clarity, with no signs of precipitation
upon visual examination under normal light conditions.