The compatibility and stability of octreotide acetate in the presence of diamorphine hydrochloride in polypropylene syringes

Varying concentrations of octreotide acetate (Sandostatin(R)) and diamorphi ne hydrochloride were prepared and stored in polypropylene syringes at 37 d egrees C in the dark. The solutions were analysed for octreotide acetate co ntent using a validated HPLC method at regular intervals over a 48-h period . The results indicate that octreotide acetate remains stable in the presen ce of diamorphine hydrochloride at 37 degrees C for 24 h. in addition, the solutions prepared maintained their clarity, with no signs of precipitation upon visual examination under normal light conditions.