Plasma brain natriuretic peptide concentrations in patients with Kawasaki disease

Background: Brain natriuretic peptide (BNP) is a cardiac hormone and plasma levels of it increase in patients with congestive heart failure and in tho se with acute myocardial infarction. Kawasaki disease (KD) is a well-known generalized vasculitis and the most prominent features of this disease are the cardiovascular manifestations, which involve the pericardium, myocardiu m, endocardium and coronary arteries. It was hypothesized that the plasma c oncentrations of BNP in patients with KD might be increased and that plasma BNP might be a useful biological marker of cardiovascular manifestations i n patients with KD. Methods: Blood was obtained to measure and compare plasma BNP concentration s in the acute (n=32) and convalescent (n=35) phases of KD and in the acute phase of the patients with viral infection (n=26), which included adenovir us, influenza, measles and herpes group virus infection. In patients with K D, two-dimensional echocardiography was performed to check for pericardial effusion and coronary arterial lesions and to measure the dimensions of the left ventricle at diastole and the shortening fraction of the left ventric le (LVSF). Results: The mean plasma BNP concentration in patients with KD in the acute phase was 55.0+/-39.5 pg/mL, but was 6.8+/-7.3 pg/mL in patients with vira l infection. The plasma BNP concentration in patients with KD in the acute phase was significantly higher than in patients with viral infection (P < 0 .0001). In 31 cases of KD, the plasma BNP concentrations were measured both in the acute and convalescent phases. The mean plasma BNP concentration in the acute phase of KD was 55.3+/-40.1 pg/mL and in the convalescent phase was 5.9+/-5.7 pg/mL. The level of plasma BNP decreased significantly in the convalescent phase (P < 0.0001). The mean BNP level in patients with KD wi th pericardial effusion (n=8) in the acute phase was 80.3+/-43.4 pg/mL and that in patients without pericardial effusion (n=24) was 46.5+/-35.1 pg/mL. The BNP level in patients with pericardial effusion was significantly high er than that of patients without pericardial effusion (P < 0.05). There was no significant correlation between the plasma concentrations of BNP in the acute phase of KD and LVSF (r=-0.161, P=0.39, n=31). Conclusion: It was shown that the plasma BNP concentration increased in the acute phase of KD and decreased to within normal range in the convalescent phase. Further examinations are needed to clarify the mechanism by which t he elevated levels of plasma BNP occur in the acute phase of KD. However, p lasma BNP might be a useful biological marker of the cardiovascular manifes tations in patients with KD.