Behavioral effect of mouse fibrinopeptide A on mouse forced swimming

A specific dopamine 2 receptor antagonist, (-)sulpiride, induced an anti-de pressive behavior, climbing, in mice forced to swim for 6 h after the injec tion. The effective fraction was divided from the mouse serum using an ion exchanger and an ultra filtration method. This fraction contained fibrinope ptide A. A peptide synthesized according to the primary 6-amino acid sequen ce (TDTEDK) of fibrinopeptide A also remarkably increased the behavior. The present findings clearly indicate that a peptide with TDTEDK showed anti-d epressive activity. (C) 2000 Elsevier Science Inc. All rights reserved.