The effective Hamiltonian for two-dimensional quantum wells with rough inte
rfaces is formally derived. Two terms are generated. The first term is iden
tified with local energy-level fluctuations, and was introduced phenomenolo
gically in the literature for interface roughness scattering, however, is n
ow shown to be valid only for an infinite potential well or Hamiltonians wi
th one single length scale. The other term is shown to modulate the wave fu
nction and cause fluctuations in the charge density. This will further redu
ce the electron mobility to a magnitude that is close to the experimental r
esult.