Sex differences in the response of postprandial lipemia to a change from alow-fat low-cholesterol diet to a high-fat high-cholesterol diet

To determine whether a short-term change in dietary habits affects postpran dial lipemia in men and women in the same way, postprandial triglyceridemia was measured in age- and BMI-matched young healthy men and women after two weeks on the self-selected low-fat low-cholesterol (LF) diet and after ano ther two weeks on the self-selected high-fat high-cholesterol (HF) diet. Af ter a standardized challenge meal (1.4 g fat/kg of body weight), men had hi gher postprandial triglyceridemia than women on the HF diet but no such dif ference was observed on the LF diet. The results of this preliminary study suggest that there may be important sex differences in the mechanisms regul ating the postprandial lipemia response to different diets, women being abl e to adapt better to the HF diet with respect to postprandial lipemia.