The cyanobacterium Nodularia in PCC 7804, of freshwater origin, produces [L-Har(2)]nodularin

Authors
Beattie, KA Kaya, K Codd, GA
Citation
Ka. Beattie et al., The cyanobacterium Nodularia in PCC 7804, of freshwater origin, produces [L-Har(2)]nodularin, PHYTOCHEM, 54(1), 2000, pp. 57-61
Citations number
19
Categorie Soggetti
Agricultural Chemistry","Animal & Plant Sciences
Journal title
PHYTOCHEMISTRY
ISSN journal
00319422 → ACNP
Volume
54
Issue
1
Year of publication
2000
Pages
57 - 61
Database
ISI
SICI code
0031-9422(200005)54:1<57:TCNIP7>2.0.ZU;2-5
Abstract
The cyanobacterium Nodularia PCC 7804, an axenic, non gas-vacuolate strain from a freshwater source, produces several metabolites with cyanobacterial hepatotoxin characteristics. The most abundant is a cyclic pentapeptide, [L -Homoarginine(2)]nodularin. [L-Har(2)]nodularin is of similar toxicity, in terms of bioassay in vivo, and the inhibition of protein phosphatase-1 in v itro to nodularin, which was present in lesser amounts in the cultures. (C) 2000 Elsevier Science Ltd. All rights reserved.