In the United States, public concern that exposure to powerline fields was
linked to cancer led to the establishment of a Congressionally mandated pro
gram, the Electric and Magnetic Fields Research and Public Information Diss
emination (ERF-RAPID) Program. A major goal of the program was to "determin
e whether or not exposures to electric and magnetic fields produced by the
generation, transmission, and use of electrical energy affect human health"
. Between 1994 and 1998, the EMF-RAPID program spent approximately $41 mill
ion on biological research. Much of the work funded by the EMF-RAPID progra
m has not yet been published in the peer-reviewed literature. The U.S. Nati
onal Institute of Environmental Health Sciences (NIEHS) asked that Radiatio
n Research publish this special issue in an attempt to remedy this publicat
ion gap. The issue includes reviews of studies that were done to assess the
biological plausibility of claims that power-frequency fields caused leuke
mia and breast cancer. The issue continues with two teratology studies and
one immunology study, The section of the issue covering in vitro studies be
gins with an overview of the efforts NIEHS made to replicate a wide range o
f reported effects of power-frequency fields and continues with four papers
reporting the absence of effects of power-frequency fields on the expressi
on of stress-response genes and oncogenes, Other reports of ill vitro studi
es and studies of mechanisms cover cytotoxicity, gap junction intracellular
communication, calcium ion transport across the plasma membrane, and intra
cellular electric fields. (C) 2000 by Radiation Research Society.