Clinical, cardiopulmonary, hematological and serum biochemical effects of sevoflurane and isoflurane anesthesia in oxygen under spontaneous breathingin sheep

Effects of sevoflurane and isoflurane anesthesia in oxygen on clinical, car diopulmonary, hematological, and serum biochemical findings were compared i n sheep breathing spontaneously undergoing minor surgical operations during shortterm (60-80min) or long-term (3-4 h) anesthesia. All sheep were preme dicated with atropine sulfate (0.1mg/kg) intramuscularly, and 10 min later, induced to anesthesia by intravenous infusion of sodium thiopental (mean 1 4.1 +/- 3.4 S.D. mg/kg). After intubation, they were anesthetized with eith er isoflurane or sevoflurane in oxygen at a total gas flow rate of 1.5 I/ m in. The results revealed that recovery time with sevoflurane was more rapid than with isoflurane. Respiration rates, tidal volume, minute ventilation and heart rates during sevoflurane anesthesia were similar to those during isoflurane anesthesia. The degree of respiratory acidosis during sevofluran e anesthesia was also similar to that during isoflurane anesthesia. There w ere no significant differences between sevoflurane and isoflurane anesthesi a in hematological and serum biochemical values. (C) 2000 Elsevier Science B.V. All rights reserved.