Proteinase N-catalysed transesterifications in DMSO-water and DMF-water: preparation of sucrose monomethacrylate

Authors
Potier, P Bouchu, A Descotes, G Queneau, Y
Citation
P. Potier et al., Proteinase N-catalysed transesterifications in DMSO-water and DMF-water: preparation of sucrose monomethacrylate, TETRAHEDR L, 41(19), 2000, pp. 3597-3600
Citations number
20
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
19
Year of publication
2000
Pages
3597 - 3600
Database
ISI
SICI code
0040-4039(20000506)41:19<3597:PNTIDA>2.0.ZU;2-I
Abstract
The selective acylation of sucrose was catalysed by proteinase N (from Baci llus subtilis) in DMF suspensions, providing 1'-monoesters, and notably, me thacryloyl esters. Presence of water up to 7% (vol.) led to faster reaction s. Alternatively, a slurry of the enzyme with a minimum volume of DMSO coul d also be used, despite its ability to denature enzymes. (C) 2000 Elsevier Science Ltd. All rights reserved.