Quantification of thiodiglycol in human urine after an accidental sulfur mustard exposure

A case of accidental human exposure to sulfur mustard, the chemical warfare agent, was documented The exposure produced shin damage in, the form of er ythema and blisters comprising less than 5% of the body surface area. Analy tical methods verified and quantitatively analyzed the exposure by observin g urinary thiodiglycol levels using gas chromatography-mass spectrometry. A maximum thiodiglycol urinary excretion rate of 20 mu g/day was reached at day 3. Concentrations over 10 ng/mL were seen for as long as a week postexp osure using the standard assay. First-order analysis of the elimination dat a yielded a thiodiglycol half-life of 1.2 d.