For thousands of years, microorganisms have been used to supply products su
ch as bread, beer and wine. A second phase of traditional microbial biotech
nology began during World War I and resulted in the development of the acet
one-butanol and glycerol fermentations, followed by processes yielding, for
example, citric acid, vitamins and antibiotics. In the early 1970s, tradit
ional industrial microbiology was merged with molecular biology to yield mo
re than 40 biopharmaceutical products, such as erythropoietin, human growth
hormone and interferons. Today, microbiology is a major participant in glo
bal industry, especially in the pharmaceutical, food and chemical industrie
s.