Poromas have been classified as eccrine neoplasms, but several recent repor
ts of poroid tumors with sebaceous, follicular, and apocrine differentiatio
n have challenged this concept. We report a case of apocrine poroma with se
baceous differentiation. A 69-year-old man presented with an asymptomatic e
levated erythematous plaque. Histopathology revealed cellular nests compose
d of cuboidal poroid cells and sebocytes. The nests varied in size and were
entirely intraepidermally arranged in a growth pattern similar to that of
hidroacanthoma simplex. Given the common embryologic origin of folliculoseb
aceous and apocrine units, we believe that this lesion represents an apocri
ne poroma with sebaceous differentiation.