Pleomorphic angioleiomyoma - Report of two cases with immunohistochemical studies

We describe two cases of pleomorphic angioleiomyoma. In one case, a 46-year -old man presented with a single nodule on his scrotum of 1 year's duration , and in another, a 38-year-old woman presented with a single nodule on her right knee of I year's duration. In both cases, histopathologic examinatio n showed a well-circumscribed nodule composed of smooth muscle and numerous veins and capillaries. Contrary to the ordinary angioleiomyoma, marked nuc lear pleomorphism was noted. Although mitoses were rare, immunohistochemist ry revealed many tumor cells that were positive for proliferating cell nucl ear antigen, Ki-67, and p53, indicating that the pleomorphic appearance doe s not simply represent a degenerative change of some tumor cells.