Herpes simplex virus DNA identification from aqueous fluid in Fuchs heterochromic iridocyclitis

PURPOSE: To report the presence of herpes simplex virus DNA in the aqueous humor of an eye with Fuchs heterochromic iridocyclitis. METHODS: In an eye with a clinical diagnosis of Fuchs heterochromic iridocy clitis, samples of aqueous humor and anterior capsule of the lens were obta ined during cataract surgery. Polymerase chain reaction was per formed on t he samples to detect the presence of viral DNA including herpes simplex vir us, varicella-zoster virus, and cytomegalovirus. Serologic analysis was als o performed for antiviral immunoglobulins, RESULTS: Herpes simplex virus DNA was identified in the aqueous humor but n ot in the anterior capsule, Serum immunoglobulin G was positive for herpes simplex virus, varicella-zoster virus, and cytomegalovirus, CONCLUSIONS: The presence of herpes simplex virus DNA in the aqueous humor of an eye with Fuchs heterochromic iridocyclitis suggests that herpes simpl ex virus infection may play a role in the pathogenesis of Fuchs heterochrom ic iridocyclitis. (C) 2000 by Elsevier Science Inc, All rights reserved.