No clinically important effects on intraocular pressure after short-term administration of sildenafil citrate (Viagra)

PURPOSE: To assess the short-term effects of sildenafil citrate on intraocu lar pressure in healthy male volunteers and participants in clinical trials . METHODS: Intraocular pressure and pupil diameter were measured in two place bo-controlled studies. Oral doses of sildenafil citrate (VIAGRA; Pfizer Inc , New York, New York) ranged from 10 mg to 150 mg, RESULTS: No major changes in intraocular pressure or pupillometry were dete cted at any time (1.0-24 hours) after administration of sildenafil. Additio nally, of 36 subjects with a medical history of increased intraocular press ure in the sildenafil safety database, none were reported to have a clinica lly significant increase of their intraocular pressure. During clinical tri als, two glaucoma cases were listed as serious adverse events, but were not considered treatment related. CONCLUSION: No clinical abnormalities were observed in intraocular pressure or pupil diameter in subjects receiving sildenafil. Currently, no evidence suggests that longterm treatment with sildenafil has an effect on intraocu lar pressure or is associated with the development or worsening of glaucoma . (C) 2000 by Elsevier Science Inc. All rights reserved.