Vogt-Koyanagi-Harada's disease: 3 cases.

Background. Vogt-Koyanagi-Harada's disease is a bilateral chronic panuveiti s sometimes associated with signs of meningo-encephalic, auditory and skin and nail involvement. We report 3 cases. Case reports. The first case was a 30-year-old woman who consulted for a re d eye, low visual acuity, poliosis, and diffuse alopecia which had develope d over 9 months. The ophthalmology examination disclosed anterior uveitis w ith retinal detachment. The second patient was a 9-year-old child who devel oped poliosis, canities, and achromic lesions over a 2 month period. The op hthalmology examination disclosed low Visual acuity, irido-corneal synechia e and pigmented deposits on the anterior lens. The third patient was a 20-y ear-old man who consulted for alopecia, diffuse canities, and white body ha ir. The ophthalmology examination disclosed low visual acuity, anterior uve itis, and a serous chorio-retinal detachment. All three patients were given general corticosteroid therapy (1 mg/kg/d). The clinical course was favora ble in all cases with however one case of recurrent ocular involvement and one case of pigmentation disorders. Discussion. The diagnosis of Vogt-Koyanagi-Harada's disease was established in these three cases on the basis of the ocular and skin and nail signs. T his rare disease usually occurs in young, often female, patients. The patho genesis remains unknown. Among the three signs observed, ocular involvement is the most serious. Skin and nail signs are seen in two-thirds of cases. For rapid diagnosis and early treatment, this disease requires a multidisip linary management associating the dermatologist and the ophthalmologist.