CONVERSION OF IN-VITRO CULTURED HUMAN MONOCYTES INTO EFFECTIVE PRESENTERS OF AN HER2 NEU-ENCODED CTL PEPTIDE EPITOPE/

Tumour-derived peptides have been surveyed, in a variety of systems, f or their ability to elicit cytokine release from class I restricted T cells, Analogous studies on ovarian carcinoma have employed the antige n-processing defective T2 cell line. Purified dendritic cells (DC) hav e been reported to act as highly effective APC. A facile method was de veloped whereby DC-like cells were generated from monocyte precursors, Herein, evidence is presented suggesting DC-like cells are superior t o T?I with respect to their ability to present a defined CTL epitope a ssociated with ovarian carcinoma.