Microbiological transformation of enrofloxacin by the fungus Mucor ramannianus

Authors
Parshikov, IA Freeman, JP Lay, JO Beger, RD Williams, AJ Sutherland, JB
Citation
Ia. Parshikov et al., Microbiological transformation of enrofloxacin by the fungus Mucor ramannianus, APPL ENVIR, 66(6), 2000, pp. 2664-2667
Citations number
24
Categorie Soggetti
Biology,Microbiology
Journal title
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
ISSN journal
00992240 → ACNP
Volume
66
Issue
6
Year of publication
2000
Pages
2664 - 2667
Database
ISI
SICI code
0099-2240(200006)66:6<2664:MTOEBT>2.0.ZU;2-O
Abstract
Enrofloxacin metabolism by Mucor ramannianus was investigated as a model fo r the biotransformation of veterinary fluoroquinolones. Cultures grown in s ucrose-peptone broth were dosed with enrofloxacin. After 21 days, 22% of th e enrofloxacin remained. Three metabolites were Identified: enrofloxacin N- oxide (62% of the total absorbance), N-acetylciprofloxacin (8.0%), and dese thylene-enrofloxacin (3.5%).