Background: Onychomycosis, or fungal infection of the nail, can occur in pr
epubertal children. However, its diagnosis is often missed or the condition
is inappropriately treated with topical medication. Griseofulvin has been
the therapy of choice, but even long-term treatment is associated with a po
or cure rate and high rare of relapse. Trials with adult patients have show
n that itraconazole pulse therapy for onychomycosis requires a shorter dura
tion of total therapy than griseofulvin treatment and is rarely associated
with adverse reactions, suggesting that it may be the treatment of choice f
or pediatric patients with onychomycosis.
Design: We retrospectively reviewed the courses of prepubertal patients wit
h dermatophyte onychomycosis who initiated treatment with itraconazole puls
e therapy between January 1995 and June 1998.
Setting: Urban and suburban pediatric dermatology clinics of a children's h
ospital.
Patients: Seventeen prepubertal patients met the enrollment and follow-up c
riteria. These included fungal infection of the nail(s), documented by fung
al culture and/or positive potassium hydroxide mounts of nail scrapings; at
least 1 follow-up visit; and contact by telephone or clinic visit within 2
months prior to compilation of data. In 59% of patients, a relative living
at the home had onychomycosis at the time of diagnosis.
Intervention: Patients were treated with daily to twice-daily pulses of itr
aconazole, administered for 1 week of each of 3 to 5 months.
Main Outcome Measures: Clinical cure after itraconazole therapy in patients
with documented onychomycosis and clinical and mycologic relapse after ini
tial cure. Fungal cultures were not repeated if clinical cure was noted.
Results: All but 1 patient responded fully to therapy, showing improvement
within a few months and subsequently clearance (94% clinical cure rate). No
patients experienced any clinical adverse reactions. No relapses occurred
after clinical cure during a follow-up period of 1 to 4.25 years after init
iation of therapy.
Conclusions: Itraconazole pulse therapy is effective and safe for the treat
ment of onychomycosis in children. The relapse rate in pediatric patients i
s lower than in adults, although the high frequency of onychomycosis non-pe
diatric family members suggests that the recurrence risk is increased if ot
her family members are not treated concomitantly.