The aim of this study was to determine the cadmium (Cd)-induced functional
and structural changes in gastric parietal cells of male rats exposed to hi
gh Cd for 30 d. Ln the present study, control animals were fed with normal
food and tap water; the remaining animals received Cd (15 ppm CdCl2) in dri
nking water for the same period. Receiving Cd for 30 d increased the mean b
lood Cd level, the mean tissue Cd content, and the mean blood pressure (p <
0.01, p < 0.001, p < 0.01, respectively). The basal acid output fell; howe
ver, the increases in stimulated acid output were not statistically signifi
cant. Light and electron microscopic examination revealed respectively that
(1) Cd decreases the mean parietal eel number per unit from the control va
lue of 23.46 +/- 3.84 to 19.46 +/- 2.12 (p < 0.05) and it affected preferen
tially the cells located at the distal half of the zymogenic unit and (2) i
n parietal cells, the Cd-induced alterations were characterized with swolle
n canalicular profiles, broken-down tubulovesicles, or degenerated mitochon
dria. We concluded that Cd augments the elimination rate of parietal cells
by increasing the alteration rate and reduced basal acid output can be expl
ained easily with the loss of parietal cell population.