1,1-diphenyl-2-picrylhydrazyl radical-scavenging compounds from soybean miso and antiproliferative activity of isoflavones from soybean miso toward the cancer cell lines
A. Hirota et al., 1,1-diphenyl-2-picrylhydrazyl radical-scavenging compounds from soybean miso and antiproliferative activity of isoflavones from soybean miso toward the cancer cell lines, BIOS BIOT B, 64(5), 2000, pp. 1038-1040
Guided by their DPPH radical-scavenging activity, nine compounds were isola
ted from soybean mise. Of these, 8-hydroxydaidzein, 8-hydroxygenistein and
syringic acid had as high DPPH radical-scavenging activity as that of alpha
-tocopherol. The antiproliferative activity of four of the isolated isoflav
ones toward three cancer cell lines was examined. 8-Hydroxygenistein showed
the highest activity (IC50 = 5.2 mu M) toward human promyelocytic leukemia
cells (HL-60).