N. Von Beckerath et al., Glycoprotein la gene C807T polymorphism and risk for major adverse cardiacevents within the first 30 days after coronary artery stenting, BLOOD, 95(11), 2000, pp. 3297-3301
The glycoprotein complex Ia/IIa (GP Ia/IIa) is a major collagen receptor on
platelets and other cell types, Recently, linked polymorphisms within the
coding region of the GP la gene (C807T and G873A) were identified that are
related to GP Ia/IIa surface expression. The T807/A873 allele is associated
with high expression, whereas the C807/G873 allele is associated with low
surface expression of GP Ia/IIa, Subsequently, the T807 allele was found to
be associated with coronary and cerebral infarction in younger patients. P
latelet adhesion to the vessel wall plays a pivotal role in thrombosis afte
r coronary artery stent placement, The goal of this study was to test wheth
er C807T polymorphism is associated with a higher incidence of thrombotic e
vents following coronary stenting, Consecutive patients treated with corona
ry stent placement (n = 1797) were genotyped for C807T polymorphism with po
lymerase chain reaction and allele-specific fluorogenic probes, The composi
te end point was defined as death, myocardial infarction, or urgent target
vessel revascularization within 30 days of stent implantation. The genotype
distribution of the study population was CC in 36.5%, CT in 46.7%, and TT
in 16.8% of the patients. The incidence of the composite end point was 6.5%
in T allele carriers and 5.3% in noncarriers (odds ratio for T allele carr
iage 1.23 [95% confidence interval, 0.81-1.86], P=.33), After adjusting for
other baseline characteristics, the odds ratio for the composite end point
was 1.15 (0.76-1.75). Therefore, C807T genotype has no significant influen
ce on the major adverse events occurring after coronary artery stenting. (B
lood, 2000;95:3297-3301) (C) 2000 by The American Society of Hematology.