CNS voltage-dependent Na+ channel expression and distribution in an undifferentiated and differentiated CNS cell line

Authors
Castaneda-Castellanos, DR Cano, M Wang, JKT Corbett, A Benson, D Blanck, TJJ Thornhill, WB Recio-Pinto, E
Citation
Dr. Castaneda-castellanos et al., CNS voltage-dependent Na+ channel expression and distribution in an undifferentiated and differentiated CNS cell line, BRAIN RES, 866(1-2), 2000, pp. 281-285
Citations number
23
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
866
Issue
1-2
Year of publication
2000
Pages
281 - 285
Database
ISI
SICI code
0006-8993(20000602)866:1-2<281:CVNCEA>2.0.ZU;2-N
Abstract
Upon serum removal, CAD-R1 cells undergo neurite outgrowth and an increase in voltage-dependent Na+ current (VDNaC) density without changing their act ivation and inactivation properties. Insulin and endothelial cell growth su pplement inhibited the increase in VDNaC density but not the neurite outgro wth. RI, RII, RIII Na+ channel proteins were expressed in CAD-R1 cells. The se proteins exhibited both similar and different distribution and clusterin g patterns which suggested the channel's structural differences play a role in channel distribution. (C) 2000 Elsevier Science B.V. All rights reserve d.