Effect of iodide on total antioxidant status of human serum

Citation
R. Winkler et al., Effect of iodide on total antioxidant status of human serum, CELL BIOC F, 18(2), 2000, pp. 143-146
Citations number
13
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELL BIOCHEMISTRY AND FUNCTION
ISSN journal
02636484 → ACNP
Volume
18
Issue
2
Year of publication
2000
Pages
143 - 146
Database
ISI
SICI code
0263-6484(200006)18:2<143:EOIOTA>2.0.ZU;2-6
Abstract
Free radicals and subsequent lipid peroxidation have been implicated in the pathogenesis of several degenerative and chronic diseases which are also t reated frequently in spas. There are some data arising from previous studie s which support an antioxidant or scavenging effect of iodide, being the es sential ingredient of a therapeutically used local brine. The nim of the st udy was to test the antioxidant capacity of iodide in human serum. For this reason we measured the so-called Total Antioxidant Status determined by a colorimetric method, which reflects the protection against the attack of re active oxygen species, including enzymic and non-enzymic antioxidants. Exog enous iodide applied as Nal, shows a significantly increased antioxidant ca pacity in comparison with NaCl at a concentration of 15 mu M, which is quit e comparable to the upper range of serum iodide levels achieved through bal neo-therapeutical intervention. This result is in accordance with previous results from in vitro depolymerization experiments with hyaluronic acid. Th e antioxidant effect of 15 mu M NaI has been found to be approaching the ph ysiologically relevant concentration of ascorbic acid (50 mu M). Copyright (C) 2000 John Wiley & Sons, Ltd.