Facile synthesis of optically active homocysteine from methionine

Authors
Shiraiwa, T Nakagawa, K Kanemoto, N
Citation
T. Shiraiwa et al., Facile synthesis of optically active homocysteine from methionine, CHEM LETT, (5), 2000, pp. 468-469
Citations number
7
Categorie Soggetti
Chemistry
Journal title
CHEMISTRY LETTERS
ISSN journal
03667022 → ACNP
Issue
5
Year of publication
2000
Pages
468 - 469
Database
ISI
SICI code
0366-7022(20000505):5<468:FSOOAH>2.0.ZU;2-D
Abstract
L-Methionine (L-Met) reacted with dichloroacetic acid in concentrated hydro chloric acid under refluxing to give (4S)-1,3-thiazane-2,4-dicarboxylic aci d hydrochloride [(4S)-TDC . HCl]. L-Homocysteine (L-Hcy) was obtained in an optically pure form by treatment of (4S)-TDC . HCl with hydroxylamine hydr ochloride. D-Hcy was also synthesized starting from D-Met via (4R)-TDC . HC l intermediate.