Preparation of new chiral borane-protected P,N-ferrocenyl ligands via a methoxy directed ortho-lithiation

Authors
Lotz, M Ireland, T Tappe, K Knochel, P
Citation
M. Lotz et al., Preparation of new chiral borane-protected P,N-ferrocenyl ligands via a methoxy directed ortho-lithiation, CHIRALITY, 12(5-6), 2000, pp. 389-395
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
CHIRALITY
ISSN journal
08990042 → ACNP
Volume
12
Issue
5-6
Year of publication
2000
Pages
389 - 395
Database
ISI
SICI code
0899-0042(2000)12:5-6<389:PONCBP>2.0.ZU;2-V
Abstract
We have shown that the readily prepared (ferrocenyl)benzylic methyl ethers of type 1 can be ortho-metalated with tert-BuLi with high diastereoselectiv ity. This reaction has been used to prepare new borane-protected P,N-substi tuted ferrocenes of type 2 in high diastereomeric and enantiomeric purity. The chiral heterocyclic aminophosphines 2 may be of interest as chelating l igands for asymmetric metal catalysis. (C) 2000 Wiley-Liss, Inc.