Asymmetric aldol reaction of enol trichloroacetate catalyzed by (S,S)-(EBTHI)TiCl(OMe)

Authors
Yanagisawa, A Asakawa, K Yamamoto, H
Citation
A. Yanagisawa et al., Asymmetric aldol reaction of enol trichloroacetate catalyzed by (S,S)-(EBTHI)TiCl(OMe), CHIRALITY, 12(5-6), 2000, pp. 421-424
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
CHIRALITY
ISSN journal
08990042 → ACNP
Volume
12
Issue
5-6
Year of publication
2000
Pages
421 - 424
Database
ISI
SICI code
0899-0042(2000)12:5-6<421:AAROET>2.0.ZU;2-L
Abstract
(S,S)-Ethylenebis (tetrahydroindenyl) titanium chloride methoxide, (S,S)-(E BTHI)TiCl(OMe) (3) was synthesized from the corresponding titanium dichlori de. The asymmetric aldol reaction of enol trichloroacetate of cyclohexanone 1 with aromatic aldehydes was studied in the presence of a catalytic amoun t of the chiral titanium complex 3, with the result that the optically acti ve syn aldol adduct 2 was preferentially obtained with up to 91% ee. (C) 20 00 Wiley-Liss, Inc.