Identification and mapping of swine cyclin-dependent kinase inhibitor CDKN2A and CDKN2B exon 2 sequences

Authors
Le Chalony, C Hayes, H Frelat, G Geffrotin, C
Citation
C. Le Chalony et al., Identification and mapping of swine cyclin-dependent kinase inhibitor CDKN2A and CDKN2B exon 2 sequences, CYTOG C GEN, 88(3-4), 2000, pp. 240-243
Citations number
10
Categorie Soggetti
Molecular Biology & Genetics
Journal title
CYTOGENETICS AND CELL GENETICS
ISSN journal
03010171 → ACNP
Volume
88
Issue
3-4
Year of publication
2000
Pages
240 - 243
Database
ISI
SICI code
0301-0171(2000)88:3-4<240:IAMOSC>2.0.ZU;2-V
Abstract
We have isolated the swine homologs of human CDKN2A and CDKN2B exon 2 seque nces. As in the human and mouse genomes, the exon 2 sequences of these two genes present a high level of sequence homology and are tightly linked. Usi ng fluorescence in situ hybridization, we have mapped swine CDKN2A and CDKN 2B to chromosome 1q25. This confirms the comparative mapping data among man , mouse, and swine, showing a conserved synteny among chromosome segments 9 p21, 4C3-C6, and 1q25, respectively. Copyright (C) 2000 S. Karger AG,Basel.