Minocycline-induced lupus - A systematic review

Background: Minocycline has increasingly been associated with different adv erse auto-immune reactions including drug-induced lupus, Objective: To iden tify the scope of minocycline-induced lupus and to characterise its typical features. Methods: Comprehensive Medline and Embase search of the English and non-English literature for case reports of minocyctine-induced lupus. R esults: We included 57 cases of minocycline-induced lupus (mean age +/- SD at onset: 21.6 +/- 8.6 years, median time of exposure: 19 months, range 3 d ays to 6 years). All patients showed the clinical features of polyarthralgi a/ polyarthritis often accompanied by liver abnormalities. Twelve patients had evidence of dermatological manifestations (i.e rash, livedo reticularis , oral ulceration, subcutaneous nodules, alopecia). The ANA test was positi ve in all patients. Conclusion: Long-term exposure to minocycline may be as sociated with drug-induced lupus. Baseline and periodic liver function and ANA tests accompanied by appropriate clinical monitoring are suggested for patients receiving long-term minocycline therapy. Copyright (C) 2000 S. Kar ger AG,Basel.