A case of viral warts with particular fibrillar intracytoplasmic inclusionbodies

A new type of skin wart was observed in a Japanese patient. It was characte rized by intracytoplasmic inclusions with a 'fibrillar' structure which wer e distinct from previously described wart-associated inclusions. The papill omavirus (HPV)-group-specific antigen could be detected, but DNA hybridizat ion and PCR amplification using probes or PCR primers specific for the main skin HPV genotypes (including HPV-63 which is also associated with 'filame ntous' inclusions) were negative. We consider that this cytopathic effect c ould correspond to an HPV genotype which has not yet been characterized. Co pyright (C) 2000 S. Karger AG, Basel.