Gastrointestinal effects of growth hormone

Authors
Citation
Di. Shulman, Gastrointestinal effects of growth hormone, ENDOCRINE, 12(2), 2000, pp. 147-152
Citations number
62
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
ENDOCRINE
ISSN journal
1355008X → ACNP
Volume
12
Issue
2
Year of publication
2000
Pages
147 - 152
Database
ISI
SICI code
1355-008X(200004)12:2<147:GEOGH>2.0.ZU;2-X
Abstract
GH receptor immunoreactivity is found throughout the gastrointestinal tract . GH has proliferative effects upon intestinal epithelium, and influences e nteroendocrine cell secretion, calcium absorption, and intestinal amino aci d and ion transport. The proliferative effects of GH may be reflected in th e increased incidence of neoplastic colonic polyps in individuals with long -term GH excess reported by some investigators. CH also increases hepatic c ytochrome P450 expression, potentially altering drug and steroid hormone me tabolism. Current clinical research efforts include the use of exogenous GH as a stim ulant of gut growth and adaptation in patients who have undergone massive i ntestinal resection. Exogenous CH is also being studied in animal models of critical illness where it appears to increase intestinal glutamine uptake, which may prevent deterioration of the intestinal mucosal barrier.