This payer considers the health effects of air pollution from three pe
rspectives: historical, statistical, and public policy, and also as de
picted by the recent epidemiology, primarily mortality studies. The hi
storical perspectives establish the reality of population-based health
effects, and they provide data with which to evaluate more recent evi
dence. Statistical perspectives imply that, while there is strong evid
ence that associations between air quality and health persist, many de
tails of these relationships remain obscure, especially as to the exis
tence of concentration thresholds that might define safe exposure leve
ls. Additional major questions include the effects of uncertainties in
actual pollution exposures, the degree of prematurity of ''excess'' d
eaths, and whether the development of new cases of chronic disease is
associated with air pollution. public policy issues center around inte
rpreting the new epidemiological studies in the light of these uncerta
inties and the analysis and management of the concomitant health risks
.