This paper is one in a series that describes results of a benchmarking
analysis initiated by the Department of Energy (DOE) and the United S
tates Environmental Protection Agency (EPA). An overview of the study
is provided in a companion paper by Laniak et al. presented in this jo
urnal issue. The three models used in the study-RESRAD (DOE), MMSOILS
(EPA), and MEPAS (DOE)-represent analytically-based tools that are use
d by the respective agencies for performing human exposure and health
risk assessments. Both single media and multimedia benchmarking scenar
ios were developed and executed. in this paper, the multimedia scenari
o is examined. That scenario consists of a hypothetical landfill that
initially contained uranium-238 and methylene chloride. The multimedia
models predict the fate of these contaminants, plus the progeny of ma
nium-238, through the unsaturated zone, saturated zone, surface water,
and atmosphere. Carcinogenic risks are calculated from exposure to th
e contaminants via multiple pathways. Results of the tests show that d
ifferences in model endpoint estimates arise from both differences in
the models' mathematical formulations and assumptions related to the i
mplementation of the scenarios.