Drug related clinical pattern in fixed drug eruption

Fixed drug eruption (FDE) represents a frequent type of drug eruption in Tu rkey. The aim of this open study is to analyze the clinical features with s pecial emphasize on drug related pattern in our case series. Sixty-four cases with established FDE by oral provocation were clinically e valuated. Cotrimoxazole, a combination of sulfamethoxazole and trimethoprim , was the most common offender for FDE (75%), followed by naproxen sodium ( 12.5%), dipyrone (9.5%), dimenhydrinate (1.5%) and paracetamol (1.5%), Sens itivity to more than one drug was not observed. Cotrimoxazole-induced FDE w as mainly located on male genitalia. Naproxen predominantly affected lips a nd face whereas dipyrone mainly caused FDE on trunk and extremities. Statis tical analysis revealed a significant difference only for dipyrone versus c otrimoxazole over trunk and extremities (p = 0.03). Familial occurrence, sy mmetrical and asymmetrical nonpigmenting FDE, linear FDE, solitary plaque o n the cheek, and "wandering" FDE were unusual findings of cotrimoxazole-ind uced FDE. Cotrimoxazole was the leading etiological agent in our series. Cotrimoxazol e-induced FDE had some rarely or previously unreported features, but a sign ificant relation between drugs and involved areas or clinical pattern could not be established.