The combined occurrence of macular amyloidosis and prurigo nodularis

The association of prurigo nodularis (PN) and macular amyloidosis (MA) has not been reported before. Although pruritus related frictional trauma is a well-known cause of PN, its role in the development of MA has always been q uestioned. We herein report two cases with chronic liver disease and iron d eficiency who concomitantly developed MA and PN lesions. Pruritus was the p receding factor and both lesions were confined to scratched areas. The asso ciation of two otherwise uncommon dermatoses in pruritic patients and their characteristic distribution might indicate an important role for pruritus- induced scratching in the pathogenesis of MA, too.