L. Niskanen et al., Leucine 7 to proline 7 polymorphism in the neuropeptide y gene is associated with retinopathy in Type 2 diabetes, EXP CL E D, 108(3), 2000, pp. 235-236
Citations number
5
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
In this study we tested the hypothesis that the Leu7Pro7 polymorphism in pr
epro neuropeptide Y (NPY) gene could be a risk marker for the development o
f diabetic retinopathy and analyzed a well characterized cohort of patients
with Type 2 diabetes followed-up for 10 years from the time of diagnosis.
The frequency of Leu7/Pro7-polymorphism was 9.3% (8 out of 86). At baseline
, the frequency of retinopathy in patients with the Leu7/Pro7-polymorphism
was 25% (2 out of 8) and in those without it 6.4% (5 out of 78) (p=0.126).
At IO-year the respective figures were 88% and 50% (p=0.040). The odds rati
o for Leu7/Pro7-polymorphism in logistic regression analysis adjusted for a
ge, gender and HbA1c was 8.97 (95% confidence intervals 1.09-98.0; p=0.049)
. Our finding based on elderly Finnish Type 2 diabetic subjects suggests th
at the Leu7Pro7-genotype in preproNPY gene is associated with the developme
nt of diabetic retinopathy.