Management of factor XI inhibitor for cardiac intervention: successful treatment with immunosuppressive therapy and plasma exchange

Two cases with congenital homozygous factor XI deficiency developed a facto r XI inhibitor following repeated plasma transfusions. Case 1 was given cyc lophosphamide, intravenous immunoglobulin, and steroids. The factor XI inhi bitor disappeared on day 103 and cardiac catheterization was performed with out complications after giving fresh frozen plasma. Case 2 was effectively managed by plasma exchange for cardiac catheterization and surgery. However , after five plasma exchange procedures, the same plasma volume exchange wa s not effective in shortening the activated partial thromboplastin time (AP TT). A significant heparin rebound occurred 4 h after heparin neutralizatio n with protamine sulphate for which the patient needed to have a blood clot evacuated from around the heart.