Synthesis, characterization, and biological activity of N '-trifluoromethanesulfonyl-2-aminopyridine

The synthesis, characterization and biological activity of N'-trifluorometh anesulfonyl-2-aminopyridine in connection with our studies of trifluorometh anesulfonyl derivatives of the pyridine ring have been achieved. In solutio n an equilibrium (similar to 50:50%) of the amide and imide tautomeric form s was observed, while in the solid state only the imide form was present. B iological tests on the compound showed no effect either upon the growth of Escherichia coli or on Staphylococcus aureus in the agar diffusion tests; h owever the growth of Enterococcus faecalis was effectively inhibited. (C) 2 000 John Wiley & Sons, Inc.