Perforin: more than just an effector molecule

Authors
Stepp, SE Mathew, PA Bennett, M de Saint Basile, G Kumar, V
Citation
Se. Stepp et al., Perforin: more than just an effector molecule, IMMUNOL TOD, 21(6), 2000, pp. 254-256
Citations number
26
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY TODAY
ISSN journal
01675699 → ACNP
Volume
21
Issue
6
Year of publication
2000
Pages
254 - 256
Database
ISI
SICI code
0167-5699(200006)21:6<254:PMTJAE>2.0.ZU;2-S
Abstract
Perforin mediates the destruction of virus-infected or transformed cells. H owever, the finding that perforin deficiency is the underlying cause of fam ilial hemaphagocytic lymphohistiocytosis indicates that it also regulates t he immune response.