Interleukin 16: implications for CD4 functions and HIV-1 progression

Authors
Center, DM Kornfeld, H Ryan, TC Cruikshank, WW
Citation
Dm. Center et al., Interleukin 16: implications for CD4 functions and HIV-1 progression, IMMUNOL TOD, 21(6), 2000, pp. 273-280
Citations number
47
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY TODAY
ISSN journal
01675699 → ACNP
Volume
21
Issue
6
Year of publication
2000
Pages
273 - 280
Database
ISI
SICI code
0167-5699(200006)21:6<273:I1IFCF>2.0.ZU;2-0
Abstract
In this article, David Center and colleagues clarify the controversies thai have emerged over the unique structure of interleukin it and its anti-HIV- 1 activity. Interleukin 16 is a ligand for CD4, and this implies CD4 acts a s a sentinel receptor that can switch CD4(+) T cells between immune and inf lammatory functions.