A new primate model for multiple sclerosis in the common marmoset

Authors
t'Hart, BA van Meurs, M Brok, HPM Massacesi, L Bauer, J Boon, L Bontrop, RE Laman, JD
Citation
Ba. T'Hart et al., A new primate model for multiple sclerosis in the common marmoset, IMMUNOL TOD, 21(6), 2000, pp. 290-297
Citations number
35
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY TODAY
ISSN journal
01675699 → ACNP
Volume
21
Issue
6
Year of publication
2000
Pages
290 - 297
Database
ISI
SICI code
0167-5699(200006)21:6<290:ANPMFM>2.0.ZU;2-Z
Abstract
Experimental autoimmune encephalomyelitis (EAE) in outbred marmoset monkeys (Callithrix jacchus) is a recently developed nonhuman primate model of mul tiple sclerosis. Here, Bert's Hart and colleagues compare this model to EAE in rhesus monkeys, highlighting autoimmune mechanisms in CNS inflammation and demyelination, including the role of major histocompatability complex r estriction and preclinical evaluation of innovative immunotherapies.