Molecular insights into the immunopathogenesis of follicular lymphoma

Citation
K. Stamatopoulos et al., Molecular insights into the immunopathogenesis of follicular lymphoma, IMMUNOL TOD, 21(6), 2000, pp. 298-305
Citations number
46
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY TODAY
ISSN journal
01675699 → ACNP
Volume
21
Issue
6
Year of publication
2000
Pages
298 - 305
Database
ISI
SICI code
0167-5699(200006)21:6<298:MIITIO>2.0.ZU;2-7
Abstract
Follicular lymphoma is caused by the transformation of a germinal-center-de rived B cell with a t(14;18) chromosomal translocation. The distribution of somatic mutations within immunoglobulin genes indicates that follicular-ly mphoma cells can interact with antigen. In addition, nonimmunoglobulin gene s such as BCL6 seem to undergo somatic hypermutation. Here, Kostas Stamatop oulos and colleagues relate the molecular data about immunoglobulin genes a nd the protooncogenes BCL2 and BCL6 to the pathogenesis and evolution of fo llicular lymphoma.