Study of the in vitro susceptibility of M-tuberculosis to ofloxacin in Spain

The aim of this study was to determine the proportion of antituberculosis o floxacin resistance among Mycobacterium tuberculosis strain isolates in Spa in. Over a period of one month, 213 M. tuberculosis strains collected from 14 different hospitals were studied, including strains both susceptible and resistant to primary antituberculosis drugs, In 28.1% of the strains, a mi nimum inhibitory concentration (MIC) for ofloxacin of 0.25 mu g/ml was obta ined; in 43.6% the MIC was 0.5 mu g/ml; in 22.06% it was 1 mu g/ml; and in 6.1% it was greater than or equal to 2 mu g/ mi, Ofloxacin currently seems to be an effective antimicrobial in vitro against susceptible or multiresis tant strains of M, tuberculosis in human immunodeficiency virus (HN)-negati ve or HIV-positive patients in Spain.