Relationship of symptom-onset-to-balloon time and door-to-balloon time with mortality in patients undergoing angioplasty for acute myocardial infarction
Cp. Cannon et al., Relationship of symptom-onset-to-balloon time and door-to-balloon time with mortality in patients undergoing angioplasty for acute myocardial infarction, J AM MED A, 283(22), 2000, pp. 2941
Citations number
54
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Context Rapid time to treatment with thrombolytic therapy is associated wit
h lower mortality in patients with acute myocardial infarction (MI). Howeve
r, data on time to primary angioplasty and its relationship to mortality ar
e inconclusive.
Objective To test the hypothesis that more rapid time to reperfusion result
s in lower mortality in the strategy of primary angioplasty.
Design Prospective observational study of data collected from the Second Na
tional Registry of Myocardial Infarction between June 1994 and March 1998.
Setting A total of 661 community and tertiary care hospitals in the United
States.
Subjects A cohort of 27 080 consecutive patients with acute MI associated w
ith ST-segment elevation or left bundle-branch block who were treated with
primary angioplasty.
Main Outcome Measure In-hospital mortality, compared by time from acute MI
symptom onset to first balloon inflation and by time from hospital arrival
to first balloon inflation (door-to-balloon time).
Results Using a multivariate logistic regression model, the adjusted odds o
f in-hospital mortality did not increase significantly with increasing dela
y from MI symptom onset to first balloon inflation. However, for door-to-ba
lloon time (median time 1 hour 56 minutes), the adjusted odds of mortality
were significantly increased by 41 % to 62 % for patients with door-to-ball
oon times longer than 2 hours (for 121-150 minutes: odds ratio [OR], 1.41;
95% confidence interval [CI], 1.08-1.84; P = .01; for 151- 180 minutes: OR,
1.62, 95 % CI, 1.2 3 -2.14; P < .001; and for >180 minutes, OR, 1.61; 95%
CI, 1.25-2.08; P < .001).
Conclusions The relationship in our study between increased mortality and d
elay in door-to-balloon time longer than 2 hours (present in nearly 50% of
this cohort) suggests that physicians and health care systems should work t
o minimize door-to-balloon times and that door-to-balloon time should be co
nsidered when choosing a reperfusion strategy. Door-to-balloon time also ap
pears to be a valid quality-of-care indicator.